Enzyme (re)design: lessons from natural evolution and computation.
نویسندگان
چکیده
The (re)design of enzymes to catalyze 'new' reactions is a topic of considerable practical and intellectual interest. Directed evolution (random mutagenesis followed by screening/selection) has been used widely to identify novel biocatalysts. However, 'rational' approaches using either natural divergent evolution or computational predictions based on chemical principles have been less successful. This review summarizes recent progress in evolution-based and computation-based (re)design.
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عنوان ژورنال:
- Current opinion in chemical biology
دوره 13 1 شماره
صفحات -
تاریخ انتشار 2009